Lee, L., Boorman, L., Glendenning, E. et al. (7 more authors) (2020) Key aspects of neurovascular control mediated by specific populations of inhibitory cortical interneurons. Cerebral Cortex, 30 (4). pp. 2452-2464. ISSN 1047-3211
Abstract
Inhibitory interneurons can evoke vasodilation and vasoconstriction, making them potential cellular drivers of neurovascular coupling. However, the specific regulatory roles played by particular interneuron subpopulations remain unclear. Our purpose was therefore to adopt a cell-specific optogenetic approach to investigate how somatostatin (SST) and neuronal nitric oxide synthase (nNOS)-expressing interneurons might influence the neurovascular relationship. In mice, specific activation of SST- or nNOS-interneurons was sufficient to evoke haemodynamic changes. In the case of nNOS-interneurons, robust haemodynamic changes occurred with minimal changes in neural activity, suggesting that the ability of BOLD fMRI to reliably reflect changes in neuronal activity may be dependent on type of neuron recruited. Conversely, activation of SST-interneurons produced robust changes in evoked neural activity with shallow cortical excitation and pronounced deep layer cortical inhibition. Prolonged activation of SST-interneurons often resulted in an increase in blood volume in the centrally activated area with an accompanying blood volume decrease in surrounding brain regions, analogous to the negative BOLD signal. These results demonstrate the role of specific populations of cortical interneurons in the active control of neurovascular function.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 The Author(s). Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
Keywords: | BOLD fMRI; neurovascular coupling; nitric oxide synthase; optogenetics; somatostatin |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > Department of Psychology (Sheffield) |
Funding Information: | Funder Grant number Medical Research Council MR/M013553/1 Wellcome Trust (The) 105586/Z/14/Z |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 13 Nov 2019 15:15 |
Last Modified: | 16 Dec 2021 09:59 |
Status: | Published |
Publisher: | Oxford University Press (OUP) |
Refereed: | Yes |
Identification Number: | 10.1093/cercor/bhz251 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:151200 |
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