Packer, J R, Hirst, A M, Droop, A P et al. (6 more authors) (2019) Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments. FEBS Letters. ISSN 0014-5793
Abstract
Low Temperature Plasma (LTP) generates reactive oxygen and nitrogen species, causing cell death, similarly to radiation. Radiation resistance results in tumour recurrence, however mechanisms of LTP resistance are unknown. LTP was applied to patient-derived prostate epithelial cells and gene expression assessed. A typical global oxidative response (AP-1 and Nrf2 signalling) was induced, whereas Notch signalling was activated exclusively in progenitor cells. Notch inhibition induced expression of prostatic acid phosphatase (PAP), a marker of prostate epithelial cell differentiation, whilst reducing colony forming ability and preventing tumour formation. Therefore, if LTP is to be progressed as a novel treatment for prostate cancer, combination treatments should be considered in the context of cellular heterogeneity and existence of cell type-specific resistance mechanisms.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | ©2019 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. |
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Sciences (York) > Physics (York) The University of York > Faculty of Sciences (York) > Biology (York) > Yorkshire Cancer Research Unit (York) |
Depositing User: | Pure (York) |
Date Deposited: | 17 Sep 2019 10:00 |
Last Modified: | 23 Jan 2025 00:21 |
Published Version: | https://doi.org/10.1002/1873-3468.13589 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/1873-3468.13589 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:150977 |
Download
Filename: Packer_et_al_2019_FEBS_Letters.pdf
Description: Packer_et_al-2019-FEBS_Letters
Licence: CC-BY 2.5