Furse, S, Billing, G, Snowden, SG et al. (3 more authors) (2019) Relationship between the lipid composition of maternal plasma and infant plasma through breast milk. Metabolomics, 15. 129. ISSN 1573-3882
Abstract
Introduction:
This study was motivated by the report that infant development correlates with particular lipids in infant plasma.
Objective:
The hypothesis was that the abundance of these candidate biomarkers is influenced by the dietary intake of the infant.
Methods:
A cohort of 30 exclusively-breastfeeding mother–infant pairs from a small region of West Africa was used for this observational study. Plasma and milk from the mother and plasma from her infant were collected within 24 h, 3 months post partum. The lipid, sterol and glyceride composition was surveyed using direct infusion MS in positive and negative ion modes. Analysis employed a combination of univariate and multivariate tests.
Results:
The lipid profiles of mother and infant plasma samples are similar but distinguishable, and both are distinct from milk. Phosphatidylcholines (PC), cholesteryl esters (CEs) and cholesterol were more abundant in mothers with respect to their infants, e.g. PC(34:1) was 5.66% in mothers but 3.61% in infants (p = 3.60 × 10−10), CE(18:2) was 8.05% in mothers but 5.18% in infants (p = 1.37 × 10−11) whilst TGs were lower in mothers with respect to their infants, e.g. TG(52:2) was 2.74% in mothers and 4.23% in infants (p = 1.63 × 10−05). A latent structure model showed that four lipids in infant plasma previously shown to be biomarkers clustered with cholesteryl esters in the maternal circulation.
Conclusion:
This study found evidence that the abundance of individual lipid isoforms associated with infant development are associated with the abundance of individual molecular species in the mother’s circulation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
Keywords: | Candidate biomarkers; Lipids; Glycerides; Infant development; Breastfeeding |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Chemistry and Biochemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 12 Sep 2019 13:26 |
Last Modified: | 18 Nov 2019 14:26 |
Status: | Published |
Publisher: | Springer Verlag |
Identification Number: | 10.1007/s11306-019-1589-z |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:150740 |
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