Tickner, Benjamin James, Lewis, Jennifer Sunari, John, Richard Owain et al. (2 more authors) (2019) Mechanistic Insight into Novel Sulfoxide Containing SABRE Polarisation Transfer Catalysts. Dalton Transactions. ISSN 1477-9234
Abstract
Signal Amplification By Reversible Exchange (SABRE) is a hyperpolarisation technique that commonly uses [Ir(H)2(carbene)(substrate)3]Cl complexes to catalytically transfer magnetisation from para-hydrogen derived hydride ligands to coordinated substrates. Here, we explore the reactivity of a novel class of such catalysts based on sulfoxide containing [IrCl(H)2(carbene)(DMSO)2], which are involved in the hyperpolarisation of pyruvate using SABRE. We probe the reactivity of this species by NMR and DFT and upon reaction with sodium pyruvate establish the formation of two isomers of [Ir(H)2(η2-pyruvate)(DMSO)(IMes)]. Studies with related disodium oxalate yield [Ir2(H)4(IMes)2(DMSO)2(κ2-η2-Oxalate)] that is characterised by NMR and X-ray diffraction.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2019 |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number WELLCOME TRUST 098335/Z/12/Z MEDICAL RESEARCH COUNCIL (MRC) MR/M008991/1 |
Depositing User: | Pure (York) |
Date Deposited: | 10 Sep 2019 09:40 |
Last Modified: | 21 Jan 2025 17:41 |
Published Version: | https://doi.org/10.1039/c9dt02951f |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1039/c9dt02951f |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:150692 |