Ghouri, A orcid.org/0000-0003-2514-5022 and Conaghan, PG orcid.org/0000-0002-3478-5665 (2019) Treating osteoarthritis pain: recent approaches using pharmacological therapies. Clinical and Experimental Rheumatology, 37 (Issue 5, Suppl. 120). CER12738. S-124-S-129. ISSN 0392-856X
Abstract
Osteoarthritis (OA) is a debilitative, painful condition with significant global burden. Pharmacological options have limited analgesic efficacy and their side-effects often restrict their use. Novel pharmacological options are needed to relieve patient symptoms and their consequent disease impact. A variety of pharmacological options have been investigated in treating OA, including existing therapies previously used for treating other arthritides (such as colchicine and hydroxychloroquine) and new therapies targeting pain (including monoclonal antibodies to nerve growth factor and intra-articular trans-capsaicin). Extended-release triamcinolone may offer more persisting analgesic effects compared to immediate-release preparations. While most studies have been unsuccessful, pharmacological therapies targeting peripheral nociceptive pathways appear promising.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Keywords: | DAMPs; osteoarthritis; corticosteroids; nociceptive pain; disease-modifying osteoarthritis drugs; cartilage; inflammation; synovitis |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Musculoskeletal Medicine & Imaging (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Sep 2019 11:29 |
Last Modified: | 12 Nov 2019 16:25 |
Status: | Published |
Publisher: | Clinical and Experimental Rheumatology Sas |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:150524 |