Pilborough, A.E. orcid.org/0000-0002-4090-7251, Lambert, D.W. orcid.org/0000-0001-9003-3145 and Khurram, S.A. orcid.org/0000-0002-0378-9380 (2019) Extranodal extension in oral cancer : a role for the nodal microenvironment? Journal of Oral Pathology & Medicine, 48 (10). pp. 863-870. ISSN 0904-2512
Abstract
Oral squamous cell carcinoma (OSCC) is a significant cause of morbidity and mortality worldwide and accounts for the majority of head and neck cancers. Metastasis of primary tumours, primarily to cervical lymph nodes in the neck, is associated with worsening prognosis. Furthermore, the prognosis of patients with extranodal extension of metastatic tumour from the lymph nodes into the neck tissues is particularly poor. The factors affecting this process are poorly understood, and detection is difficult pre‐surgery. Mounting evidence shows that components of the tumour microenvironment including cancer‐associated fibroblasts, vascular and lymphatic endothelial cells, the extracellular matrix and inflammatory immune cells, are important modulators of tumour behaviour in primary OSCC and other cancers. However, little is known about the lymph node microenvironment, its response to tumour presence and role in extranodal extension. In addition, there are many lymph node‐specific cell types and structures, such as fibroblast reticular cells and high endothelial venules, making the lymph node microenvironment distinct from that found at primary tumour sites, and which contribute to the nodal response to tumour presence. This review details the current knowledge regarding the lymph node tumour microenvironment in OSCC and its role in lymph node metastasis and extranodal extension and relates this to features of the primary tumour. Understanding the role that the lymph node microenvironment plays in promoting tumour development and extranodal extension may aid the identification of novel biomarkers and alternative treatment strategies to improve the prognosis of patients with advanced OSCC.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2019 John Wiley & Sons. This is an author-produced version of a paper subsequently published in Journal of Oral Pathology & Medicine. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | extracapsular spread; extranodal extension; lymph node metastasis; oral cancer; oral squamous cell carcinoma; tumour microenvironment |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) > School of Clinical Dentistry (Sheffield) |
Funding Information: | Funder Grant number Academy Of Medical Sciences N/a |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 04 Sep 2019 11:48 |
Last Modified: | 10 Dec 2021 13:42 |
Status: | Published |
Publisher: | Wiley |
Refereed: | Yes |
Identification Number: | 10.1111/jop.12870 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:150419 |