Levick, BA orcid.org/0000-0002-6371-8744, Gilbert, AJ, Spencer, KL orcid.org/0000-0002-6846-4341 et al. (5 more authors) (2020) Time to Surgery Following Short-Course Radiotherapy in Rectal Cancer and its Impact on Postoperative Outcomes. A Population-Based Study Across the English National Health Service, 2009–2014. Clinical Oncology, 32. e46-e52. ISSN 0936-6555
Abstract
Aims
Preoperative short-course radiotherapy (SCRT) is an important treatment option for rectal cancer. The length of time between completing SCRT and surgery may influence postoperative outcomes, but the evidence available to determine the optimal interval is limited and often conflicting.
Materials and methods
Information was extracted from a colorectal cancer data repository (CORECT-R) on all surgically treated rectal cancer patients who received SCRT in the English National Health Service between April 2009 and December 2014. The time from radiotherapy to surgery was described across the population. Thirty-day postoperative mortality, returns to theatre, length of stay and 1-year survival were investigated in relation to the interval between radiotherapy and surgery.
Results
Within the cohort of 3469 patients, the time to surgery was 0–7 days for 76% of patients, 8–14 days for 19% of patients and 15–27 days for 5% of patients. There was a clear variation in relation to different patient characteristics. There was, however, no evidence of differences in postoperative outcomes in relation to interval length.
Conclusions
This study suggests that the time interval between SCRT and surgery does not influence postoperative outcomes up to a year after surgery. The study provides population-level, real-world evidence to complement that from clinical trials.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2019 The Royal College of Radiologists. Published by Elsevier Ltd. This is an open access article under the CC-BY license (http://creativecommons.org/licenses/by/4.0/) |
Keywords: | Cancer; interval; neoadjuvant; outcomes; rectal; short-course radiotherapy |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Biomed & Clin Sciences (LIBACS) (Leeds) > Trans Anaesthetics & Surgical Sciences (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Health Sciences (Leeds) > Academic Unit of Health Economics (Leeds) |
Funding Information: | Funder Grant number Cancer Research UK C23434/A23706 Yorkshire Cancer Research L394 Academy of Medical Sciences N/A Cancer Research UK A28301 |
Depositing User: | Symplectic Publications |
Date Deposited: | 03 Sep 2019 11:25 |
Last Modified: | 25 Jun 2023 21:58 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.clon.2019.08.008 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:150266 |