Mai, C, Mankoo, H, Wei, L et al. (4 more authors) (2020) TRPM2 channel: A novel target for alleviating ischaemia‐reperfusion, chronic cerebral hypo‐perfusion and neonatal hypoxic‐ischaemic brain damage. Journal of Cellular and Molecular Medicine, 24 (1). pp. 4-12. ISSN 1582-1838
Abstract
The transient receptor potential melastatin-related 2 (TRPM2) channel, a reactive oxygen species (ROS)-sensitive cation channel, has been well recognized for being an important and common mechanism that confers the susceptibility to ROS-induced cell death. An elevated level of ROS is a salient feature of ischemia-reperfusion, chronic cerebral hypo-perfusion and neonatal hypoxia-ischemia. The TRPM2 channel is expressed in hippocampus, cortex and striatum, the brain regions that are critical for cognitive functions. In this review, we examine the recent studies that combine pharmacological and/or genetic interventions with using in vitro and in vivo models to demonstrate a crucial role of the TRPM2 channel in brain damage by ischemia-reperfusion, chronic cerebral hypo-perfusion and neonatal hypoxic-ischemia. We also discuss the current understanding of the underlying TRPM2-dependent cellular and molecular mechanisms. These new findings lead to the hypothesis of targeting the TRPM2 channel as a potential novel therapeutic strategy to alleviate brain damage and cognitive dysfunction caused by these conditions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | brain damage; chronic cerebral hypo‐perfusion; ischaemia‐reperfusion; neonatal hypoxia‐ischaemia; reactive oxygen species; TRPM2 channel |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 02 Sep 2019 09:45 |
Last Modified: | 25 Jun 2023 21:58 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/jcmm.14679 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:150227 |