Turner, NA orcid.org/0000-0002-4957-5433 and Porter, KE orcid.org/0000-0002-6442-7420 (2012) Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblasts. IUBMB Life, 64 (2). pp. 143-150. ISSN 1521-6543
Abstract
Cardiac fibroblasts (CF) play a key role in orchestrating the structural remodeling of the myocardium in response to injury or stress, in part through direct regulation of extracellular matrix (ECM) turnover. The matrix metalloproteinases (MMPs) are a family of over 25 zinc‐dependent proteases that together have the capacity to degrade all the protein components of the ECM. Fibroblasts are a major source of several MMPs in the heart, thereby representing a viable therapeutic target for regulating ECM turnover in cardiac pathologies characterized by adverse remodeling, such as myocardial infarction, cardiomyopathy, hypertension and heart failure. This review summarizes current knowledge on the identity and regulation of MMPs expressed by CF and discusses future directions for reducing adverse myocardial remodeling by modulating the expression and/or activity of CF‐derived MMPs. © 2012 IUBMB IUBMB Life, 2012.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2012 IUBMB IUBMB Life, 2012. This is the peer reviewed version of the following article: Turner, N.A. and Porter, K.E. (2012), Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblasts. IUBMB Life, 64: 143-150. doi:10.1002/iub.594 , which has been published in final form at http://doi.org/10.1002/iub.594. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Keywords: | Cardiac fibroblast; matrix metalloproteinase; signal transduction; transcription; myocardium; extracellular matrix ; remodeling ; cytokines ; growth factors |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Specialist Science Education Dept (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 27 Feb 2020 09:55 |
Last Modified: | 28 Feb 2020 11:17 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/iub.594 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:149969 |