Indelicato, Giuliana, Cermelli, Paolo and Twarock, Reidun orcid.org/0000-0002-1824-2003 (2019) A coarse-grained model of the expansionof the human rhinovirus 2 capsid revealsinsights in genome release. Journal of the Royal Society Interface. 20190044. ISSN 1742-5662
Abstract
Human rhinoviruses are causative agents of the common cold. In order torelease their RNA genome into the host during a viral infection, these smallviruses must undergo conformational changes in their capsids, whosedetailed mechanism is strictly related to the process of RNA extrusion,which has been only partially elucidated. We study here a mathematicalmodel for the structural transition between the native particle of human rhi-novirus type 2 and its expanded form, viewing the process as an energycascade, i.e. a sequence of metastable states with decreasing energy connectedby minimum energy paths. We explore several transition pathways anddiscuss their implications for the RNA exit process
Metadata
Item Type: | Article |
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Authors/Creators: |
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Keywords: | minimum energy paths,energy landscape,viral structuraltransitions |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Mathematics (York) The University of York > Faculty of Sciences (York) > Biology (York) |
Funding Information: | Funder Grant number EPSRC EP/R023204/1 |
Depositing User: | Pure (York) |
Date Deposited: | 21 Aug 2019 15:50 |
Last Modified: | 16 Oct 2024 15:57 |
Published Version: | https://doi.org/10.1098/rsif.2019.0044 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1098/rsif.2019.0044 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:149929 |