Rational redox tuning of transition metal sites:Learning from superoxide reductase
Horch, Marius
(2019)
Rational redox tuning of transition metal sites:Learning from superoxide reductase.
Chemical Communications.
pp. 9148-9151.
ISSN 1364-548X
Abstract
Using superoxide reductase as a model system, a computational approach reveals how histidine tautomerism tunes the redox properties of metalloenzymes to enable their catalytic function. Inspired by these experimentally inaccessible insights, non-canonical histidine congeners are introduced as new versatile tools for the rational engineering of biological transition metal sites.
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Article
Authors/Creators:
Horch, Marius (mh1977@york.ac.uk)
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