Moens, U and Macdonald, A orcid.org/0000-0002-5978-4693 (2019) Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways. International Journal of Molecular Sciences, 20 (16). 3914. ISSN 1661-6596
Abstract
Viruses are intracellular parasites that require a permissive host cell to express the viral genome and to produce new progeny virus particles. However, not all viral infections are productive and some viruses can induce carcinogenesis. Irrespective of the type of infection (productive or neoplastic), viruses hijack the host cell machinery to permit optimal viral replication or to transform the infected cell into a tumor cell. One mechanism viruses employ to reprogram the host cell is through interference with signaling pathways. Polyomaviruses are naked, double-stranded DNA viruses whose genome encodes the regulatory proteins large T-antigen and small t-antigen, and structural proteins that form the capsid. The large T-antigens and small t-antigens can interfere with several host signaling pathways. In this case, we review the interplay between the large T-antigens and small t-antigens with host signaling pathways and the biological consequences of these interactions.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 by the authors. Licensee MDPI, Basel, Switzerland.This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | apoptosis; DNA damage response; immune response; interferon; MAP kinase; NFκB; p53; PI3K; protein phosphatases; retinoblastoma |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) |
Funding Information: | Funder Grant number Kidney Research UK ST4/2014 Kidney Research UK RP25/2013 Kidney Research UK RP_022_20170302 Kidney Research UK ST_002_20171124 |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Aug 2019 10:12 |
Last Modified: | 13 Aug 2019 10:12 |
Status: | Published |
Publisher: | MDPI |
Identification Number: | 10.3390/ijms20163914 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:149597 |