Whitfield, T. orcid.org/0000-0003-1575-1504 (2020) Cilia in the developing zebrafish ear. Philosophical Transactions B: Biological Sciences, 375 (1792). 20190163. ISSN 0962-8436
Abstract
The inner ear, which mediates the senses of hearing and balance, derives from a simple ectodermal vesicle in the vertebrate embryo. In the zebrafish, the otic placode and vesicle express a whole suite of genes required for ciliogenesis and ciliary motility. Every cell of the otic epithelium is ciliated at early stages; at least three different ciliary subtypes can be distinguished on the basis of length, motility, genetic requirements and function. In the early otic vesicle, most cilia are short and immotile. Long, immotile kinocilia on the first sensory hair cells tether the otoliths, biomineralised aggregates of calcium carbonate and protein. Small numbers of motile cilia at the poles of the otic vesicle contribute to the accuracy of otolith tethering, but neither the presence of cilia nor ciliary motility are absolutely required for this process. Instead, otolith tethering is dependent on the presence of hair cells and function of the glycoprotein Otogelin. Otic cilia or ciliary proteins also mediate sensitivity to ototoxins and co-ordinate responses to extracellular signals. Other studies are beginning to unravel the role of ciliary proteins in cellular compartments other than the kinocilium, where they are important for the integrity and survival of the sensory hair cell.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2019 The Author(s). This is an author-produced version of a paper subsequently published in Philosophical Transactions B: Biological Sciences. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Zebrafish; otic vesicle; kinocilia; motile cilia; otolith; sensory hair cell |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) |
Funding Information: | Funder Grant number Biotechnology and Biological Sciences Research Council (BBSRC) BB/S007008/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 20 Aug 2019 09:32 |
Last Modified: | 07 Jan 2020 16:46 |
Status: | Published |
Publisher: | Royal Society, The |
Refereed: | Yes |
Identification Number: | 10.1098/rstb.2019.0163 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:149523 |