Whittington, Miles Adrian orcid.org/0000-0002-0247-1362 (2019) Parietal low beta rhythm provides a dynamical substrate for a working memory buffer. Proceedings of the National Academy of Sciences of the United States of America. ISSN 1091-6490
Abstract
Working memory (WM) is a component of the brain’s memory systems vital for interpretation of sequential sensory inputs and consequent decision making. Anatomically, WM is highly distributed over the prefrontal cortex (PFC) and the parietal cortex (PC). Here we present a biophysically detailed dynamical systems model for a WM buffer situated in the PC, making use of dynamical properties believed to be unique to this area. We show that the natural beta1 rhythm (12 to 20 Hz) of the PC provides a substrate for an episodic buffer that can synergistically combine executive commands (e.g., from PFC) and multimodal information into a flexible and updatable representation of recent sensory inputs. This representation is sensitive to distractors, it allows for a readout mechanism, and it can be readily terminated by executive input. The model provides a demonstration of how information can be usefully stored in the temporal patterns of activity in a neuronal network rather than just synaptic weights between the neurons in that network.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019, The Author(s). |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Hull York Medical School (York) |
Depositing User: | Pure (York) |
Date Deposited: | 02 Aug 2019 08:10 |
Last Modified: | 02 Apr 2025 23:16 |
Published Version: | https://doi.org/10.1073/pnas.1902305116 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1073/pnas.1902305116 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:149259 |