Latimer, Joanna orcid.org/0000-0001-7418-7515 and Hillman, Alexandra (2019) Biomarkers and brains:situating dementia in the laboratory and in the memory clinic. New Genetics and Society. pp. 1-16. ISSN 1463-6778
Abstract
This paper provides a comparison of how genetic biomarkers are used (or not) in three contexts: clinic-based diagnostic work with people; lab-based research on mice and their marbles; and lab-based research on thrashing nematodes. For all the worldwide drive to find biomarkers that can be used in the detection of early, presymptomatic dementia, there is little research on how or when the association between biomarkers and a definitive disease are being made to “hold.” First, we show the disjuncture between the animal modeling that underpins laboratory attempts to stabilize genetic biomarkers and the paradigms that inform clinical diagnosis. Secondly, we develop this theme to show how in our third site, an epigenetics “worm” laboratory, neurodegenerative changes are explored as located in specific gene-environment interactions over time. We speculate whether such an enactment brings us closer to a notion of “situated biology,” to undercut possibilities of making genetic biomarkers of preclinical dementia hold.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 The Author(s) |
Keywords: | animal models,biogerontology,dementia,epigenetics,memory clinics,mindedness |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Social Sciences (York) > Sociology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 01 Aug 2019 07:50 |
Last Modified: | 08 Feb 2025 00:34 |
Published Version: | https://doi.org/10.1080/14636778.2019.1652804 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1080/14636778.2019.1652804 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:149228 |
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Description: Biomarkers and brains situating dementia in the laboratory and in the memory clinic
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