Leech, T, Evison, SEF, Armitage, SAO et al. (2 more authors) (2019) Interactive effects of social environment, age and sex on immune responses in Drosophila melanogaster. Journal of Evolutionary Biology, 32 (10). pp. 1082-1092. ISSN 1010-061X
Abstract
Social environments have been shown to have multiple effects on individual immune responses. For example, increased social contact might signal greater infection risk and prompt a prophylactic upregulation of immunity. This differential investment of resources may in part explain why social environments affect ageing and lifespan. Our previous work using Drosophila melanogaster showed that single-sex social contact reduced lifespan for both sexes. Here, we assess how social interactions (isolation or contact) affect susceptibility to infection, phagocytotic activity and expression of a subset of immune and stress related genes in young and old flies of both sexes. Social contact had a neutral, or even improved, effect on post-infection lifespan in older flies and reduced the expression of stress response genes in females, however it reduced phagocytotic activity. Overall the effects of social environment were complex and largely subtle, and do not indicate a consistent effect. Together, these findings indicate that social contact in D. melanogaster does not have a predictable impact on immune responses and does not simply trade-off immune investment with lifespan.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2019 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2019 European Society For Evolutionary Biology. This article is protected by copyright. All rights reserved. This is the peer reviewed version of the following article: Leech, T, Evison, SEF, Armitage, SAO et al. (2 more authors) (2019) Interactive effects of social environment, age and sex on immune responses in Drosophila melanogaster. Journal of Evolutionary Biology, 32 (10). pp. 1082-1092. ISSN 1010-061X, which has been published in final form at [https://doi.org/10.1111/jeb.13509]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Keywords: | gene expression, infection, phagocytosis, senescence, stress, sex differences |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 24 Jul 2019 15:38 |
Last Modified: | 17 Jul 2020 00:38 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/jeb.13509 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:148845 |