Thanarak, J., Mohammed, H., Pashneh-Tala, S. et al. (2 more authors) (2019) Enhanced collagen production from human dermal fibroblasts on poly(glycerol sebacate)-methacrylate scaffolds. In: 2018 11th Biomedical Engineering International Conference (BMEiCON). 2018 11th Biomedical Engineering International Conference (BMEiCON), 21-24 Nov 2018, Chiang Mai, Thailand. IEEE ISBN 978-1-5386-5724-9
Abstract
Poly(glycerol sebacate)-methacrylate (PGS-M) is a photocurable form of polyglycerol sebacate (PGS) that has recently been shown to be suitable for use as a scaffold for tissue engineering. It has the benefits of PGS, including biocompatibility and biodegradability, while also being much simpler to process into a variety of 3D structures. Cell compatibility has already been demonstrated on the 30% methacrylated PGS-M scaffolds. However no studies have yet assessed the collagen produced by cells growing on the PGS-M scaffold. Here we demonstrate that 50% methacrylated PGS-M 3D scaffolds are able to support the culture of human dermal fibroblasts for 1 week. We also show that collagen production is enhanced compared with the same cells growing on tissue culture plastic, with the cells producing approximately 50% more total collagen after 1 week in culture. These results go further to demonstrate the suitability of the PGS-M scaffolds for generating ECM based constructs for soft tissue engineering.
Metadata
Item Type: | Proceedings Paper |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works. Reproduced in accordance with the publisher's self-archiving policy. |
Keywords: | tissue engineering; collagen; scaffold; fibroblasts; 3D cell culture; soft tissue |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Engineering (Sheffield) > Department of Materials Science and Engineering (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 02 Aug 2019 10:26 |
Last Modified: | 14 Jan 2020 01:39 |
Status: | Published |
Publisher: | IEEE |
Refereed: | Yes |
Identification Number: | 10.1109/BMEiCON.2018.8609928 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:148649 |