Leslie, Theresa Katharina, James, Andrew David, Zaccagna, Fulvio et al. (8 more authors) (2019) Sodium homeostasis in the tumour microenvironment. BBA - Reviews on Cancer. pp. 1-16.
Abstract
The concentration of sodium ions (Na+) is raised in solid tumours and can be measured at the cellular, tissue and patient levels. At the cellular level, the Na+ gradient across the membrane powers the transport of H+ ions and essential nutrients for normal activity. The maintenance of the Na+ gradient requires a large proportion of the cell’s ATP. Na+ is a major contributor to the osmolarity of the tumour microenvironment, which affects cell volume and metabolism as well as immune function. Here, we review evidence indicating that Na+ handling is altered in tumours, explore our current understanding of the mechanisms that may underlie these alterations and consider the potential consequences for cancer progression. Dysregulated Na+ balance in tumours may open opportunities for new imaging biomarkers and re-purposing of drugs for treatment.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Elsevier B.V. All rights reserved. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number UNSPECIFIED 2015NovPhD572 |
Depositing User: | Pure (York) |
Date Deposited: | 16 Jul 2019 09:50 |
Last Modified: | 16 Oct 2024 15:52 |
Published Version: | https://doi.org/10.1016/j.bbcan.2019.07.001 |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1016/j.bbcan.2019.07.001 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:148601 |
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