Zhuang, X, Lai, A, McKeating, J et al. (2 more authors) (2018) Daytime variation in hepatitis C virus replication kinetics following liver transplant. Wellcome Open Research, 3 (96).
Abstract
Background: There is a growing interest in the role of circadian regulated pathways in disease pathogenesis. Methods: In a cohort of hepatitis C virus (HCV) infected patients undergoing liver transplantation, we observed differences in early viral infection kinetics of the allograft that associated with the time of liver transplant. Results: A higher frequency of subjects transplanted in the morning showed a rebound in viral RNA levels (n=4/6) during the first week post-surgery. In contrast, no viral rebound was observed in seven subjects transplanted in the afternoon. None of the other parameters previously reported to influence viral replication in the post-transplant setting, such as donor age, cold-ischemia time and length of surgery associated with viral rebound. Conclusions: These observation highlights a role for circadian processes to regulate HCV infection of the liver and warrants further investigation.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2018 Zhuang X et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited |
Keywords: | HCV, Circadian rhythm, liver transplant, allograft, viral rebound, time of day |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Translational Medicine (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 15 Jul 2019 09:05 |
Last Modified: | 15 Jul 2019 09:05 |
Status: | Published |
Publisher: | F1000Research |
Identification Number: | 10.12688/wellcomeopenres.14696.2 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:148553 |