Higham, R (2019) Imagining the future of cell therapies: clinical trials, innovation and the intersection of clinical-academic and commercial visions. New Genetics and Society, 38 (4). pp. 363-386. ISSN 1463-6778
Abstract
This paper examines the role of clinical trials in regenerative medicine innovation, exploring how trials have contributed to translational challenges in the field. Using data from an ethnographic study of UK cell therapy trials I interrogate the institutional framework for clinical trials and the identity-making of trialists. This analysis uncovers a disconnect between a commercially-aligned regulatory framework and a clinical-academic identity apparent in the majority of current trialling activity. These different pathways appear to represent two distinct sociotechnical imaginaries for cell therapies; one which reflects the assumptions of commercial innovation and prioritises economic success, and another which embodies the cultural expectations of academia and emphasises the importance of clinical care. These two imaginaries operate in synergy to some extent but there are significant tensions between them. How and to what extent these tensions are reconciled is likely to determine both the long-term success and the future shape of the field.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Informa UK Limited, trading as Taylor & Francis Group. This is an Accepted Manuscript of an article published by Taylor & Francis in New Genetics and Society on 28 Jul 2019, available online: https://doi.org/10.1080/14636778.2019.1642742. |
Keywords: | clinical trials; cell therapies; regenerative medicine; co-production; sociotechnical imaginaries |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Clinical Trials Research (LICTR) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Jul 2019 12:14 |
Last Modified: | 28 Jul 2020 00:38 |
Status: | Published |
Publisher: | Taylor & Francis |
Identification Number: | 10.1080/14636778.2019.1642742 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:148422 |