Jove, M, Spencer, J, Clench, M et al. (2 more authors) (2019) Precision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance. Critical Reviews in Oncology/Hematology, 141. pp. 153-162. ISSN 1040-8428
Abstract
Failure of systemic cancer treatment can be, at least in part, due to the drug not being delivered to the tumour at sufficiently high concentration and/or sufficiently homogeneous distribution; this is termed as “pharmacokinetic drug resistance”. To understand whether a drug is being adequately delivered to the tumour, “precision pharmacology” techniques are needed. Mass spectrometry imaging (MSI) is a relatively new and complex technique that allows imaging of drug distribution within tissues. In this review we address the applicability of MSI to the study of cancer drug distribution from the bench to the bedside. We address: (i) the role of MSI in pre-clinical studies to characterize anti-cancer drug distribution within the body and the tumour, (ii) the application of MSI in pre-clinical studies to define optimal drug dose or schedule, combinations or new drug delivery systems, and finally (iii) the emerging role of MSI in clinical research.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Published by Elsevier B.V. This is an author produced version of a paper published in Critical Reviews in Oncology/Hematology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | MALDI-MSI; intra-tumoural drug distribution; drug development; pharmacokinetics |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Clinical Cancer Research (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 09 Jul 2019 12:14 |
Last Modified: | 05 Jul 2020 00:38 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.critrevonc.2019.06.008 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:148354 |
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