Carrasco Hope, H and Salmond, RJ orcid.org/0000-0002-1807-1056 (2019) Targeting the tumour microenvironment and T cell metabolism for effective cancer immunotherapy. European Journal of Immunology, 49 (8). pp. 1147-1152. ISSN 0014-2980
Abstract
The successful implementation of immunotherapies has provided new impetus in the fight against cancer. Antibody‐mediated blockade of immune checkpoint molecules PD‐1 / PD‐L1 and CTLA‐4 has had a dramatic impact upon the treatment of previously intractable cancers such as malignant melanoma, whilst adoptive cell therapies using chimeric antigen receptor‐bearing T cells have proven highly efficacious in B cell leukaemia. Furthermore, significant progress has been made in understanding the mechanisms by which tumours evade or become resistant to these immunotherapies. In this regard, approaches to broaden the applicability and enhance the efficacy of immunotherapies increasingly include modulation of tumuor and immune cell metabolism. In this mini‐review we highlight the most recent studies describing novel approaches and targets for the manipulation of the tumour microenvironment and T cell metabolism and describe how these approaches are being combined with current immunotherapies in preclinical studies.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Hope, H. C. and Salmond, R. J. (2019), Targeting the tumour micro environment and T cell metabolism for effective cancer immunotherapy. Eur. J. Immunol. Accepted Author Manuscript, which has been published in final form at https://doi.org/10.1002/eji.201848058. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. |
Keywords: | cancer; checkpoint inhibitors; immunotherapy; metabolism; T cells; tumour microenvironment |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Infection and Immunity (Leeds) |
Funding Information: | Funder Grant number Cancer Research UK C55663/A23269 |
Depositing User: | Symplectic Publications |
Date Deposited: | 09 Jul 2019 13:25 |
Last Modified: | 04 Jul 2020 00:38 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/eji.201848058 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:148256 |