Hanlon, Inna, Hewitt, Catherine Elizabeth orcid.org/0000-0002-0415-3536, Bell, Kerry Jane orcid.org/0000-0001-5124-138X et al. (2 more authors) (2018) Risk of diabetes in HIV-infected patients is associated with cirrhosis but not with chronic HCV coinfection in a French nationwide HIV cohort:Online Psychological Interventions for Mental and Physical Health Outcomes in Gastrointestinal Disorders Including Irritable Bowel Syndrome and Inflammatory Bowel Disease. Alimentary pharmacology & therapeutics. pp. 281-289. ISSN 1365-2036
Abstract
Background: Both human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections have been reportedly associated with a higher risk of diabetes mellitus (DM) but results are conflicting. Aims: To determine whether there is an association between chronic HCV and the incidence of DM, and to study the role of factors such as cirrhosis, IFN-based HCV therapy, sustained virologic response (SVR) and chronic HBV infection among patients living with HIV (PLHIV) followed in a large French multicentre cohort in the combination antiretroviral therapy (cART) era. Methods: All PLHIV followed up in the Dat’AIDS cohort were eligible. Cox models for survival analysis were used to study the time to occurrence of DM. Results: Among 28 699 PLHIV, 4004 patients had chronic HCV infection. The mean duration of HCV follow-up was 12.5 ± 8.1 years. The rate ratio of DM was 2.74 per 1000 person-years. By multivariate analysis, increasing age, body mass index>25, AIDS status, nadir CD4 cell count ≤200/mm 3, detectable HIV viral load and cirrhosis (HR 2.26 95% CI 1.14-1.18; P < 0.0001) were predictors of DM, whereas longer cART duration was associated with a lower risk of DM. Chronic HCV and HBV infection and IFN-based HCV therapy were not associated with DM. In a subanalysis among HCV-infected patients, SVR was not related to DM. Conclusions: Our study shows that in the HIV population, cirrhosis is associated with an increased occurrence of DM, but not chronic HCV infection or duration of HCV infection.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Health Sciences (York) |
Depositing User: | Pure (York) |
Date Deposited: | 13 Jun 2019 09:30 |
Last Modified: | 02 Apr 2025 23:13 |
Published Version: | https://doi.org/10.1111/apt.14812 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1111/apt.14812 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:147275 |