Mozumder, M, Pozo, JM, Coelho, S orcid.org/0000-0002-1039-4803 et al. (1 more author) (2019) Population-based Bayesian regularization for microstructural diffusion MRI with NODDIDA. Magnetic resonance in medicine, 82 (4). pp. 1553-1565. ISSN 0740-3194
Abstract
PURPOSE:Information on the brain microstructure can be probed by Diffusion Magnetic Resonance Imaging (dMRI). Neurite Orientation Dispersion and Density Imaging with Diffusivities Assessment (NODDIDA) is one of the simplest microstructural model proposed. However, the estimation of the NODDIDA parameters from clinically plausible dMRI acquisition is ill-posed, and different parameter sets can describe the same measurements equally well. A few approaches to resolve this problem focused on developing better optimization strategies for this non-convex optimization. However, this fundamentally does not resolve ill-posedness. This article introduces a Bayesian estimation framework, which is regularized through knowledge from an extensive dMRI measurement set on a population of healthy adults (henceforth population-based prior). METHODS:We reformulate the problem as a Bayesian maximum a posteriori estimation, which includes as a special case previous approach using non-informative uniform priors. A population-based prior is estimated from 35 subjects of the MGH Adult Diffusion data (Human Connectome Project), acquired with an extensive acquisition protocol including high b-values. The accuracy and robustness of different approaches with and without the population-based prior is tested on subsets of the MGH dataset, and an independent dataset from a clinically comparable scanner, with only clinically plausible dMRI measurements. RESULTS:The population-based prior produced substantially more accurate and robust parameter estimates, compared to the conventional uniform priors, for clinically feasible protocols, without introducing any evident bias. CONCLUSIONS:The use of the proposed Bayesian population-based prior can lead to clinically feasible and robust estimation of NODDIDA parameters without changing the acquisition protocol.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited |
Keywords: | Biophysical tissue models; diffusion MRI; microstructure imaging; modeling; parameter estimation |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Computing (Leeds) |
Funding Information: | Funder Grant number EPSRC EP/M006328/2 |
Depositing User: | Symplectic Publications |
Date Deposited: | 13 Jun 2019 12:24 |
Last Modified: | 25 Jun 2023 21:52 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/mrm.27831 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:147229 |