Yu, H, Ingram, N orcid.org/0000-0001-5274-8502, Rowley, J orcid.org/0000-0001-6646-1676 et al. (4 more authors) (2019) Thermoresponsive Polysarcosine-Based Nanoparticles. Journal of Materials Chemistry B, 26. pp. 4217-4223. ISSN 2050-750X
Abstract
Polysarcosine holds great promise as an alternative to poly(ethylene glycol) for use within both biomedical and non-biomedical applications owing to its hydrophilicity and non-cytoxicity, amongst other features. The grafting of a limited quantity of (N-(2-hydroxypropyl)methacrylamide) to polysarcosine, for instance 3.5% of the total copolymer in terms of the number of repeat units, has a profound effect on the properties of the copolymer formed; polymer self-assembly to yield thermoreponsive nanoparticles can now be realised. Such nanoparticles are non-cytotoxic against a range of human breast cancer cell lines, able to withhold the therapeutic compound doxorubicin, and allow pronounced doxorubicin release in response to subtle thermal stimulation. This research informs of how the straightforward modification of polysarcosine with a nominal molar amount of poly(N-(2-hydroxypropyl)methacrylamide) can yield stimuli-responsive polymers that are suitable for use within controlled release applications.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2019. This is an author produced version of an article published in Journal of Materials Chemistry B. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemical & Process Engineering (Leeds) The University of Leeds > Faculty of Engineering & Physical Sciences (Leeds) > School of Chemistry (Leeds) > Colour Science (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Molecular Gastroenterology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 Jun 2019 13:50 |
Last Modified: | 05 Jun 2020 00:38 |
Status: | Published |
Publisher: | Royal Society of Chemistry |
Identification Number: | 10.1039/c9tb00588a |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:147208 |
Commentary/Response Threads
- Yu, H, Ingram, N, Rowley, J, Parkinson, S, Green, DC, Warren, NJ and Thornton, PD Thermoresponsive Polysarcosine-Based Nanoparticles. (deposited 14 Jun 2019 13:50) [Currently Displayed]