Belibasakis, GN, Bostanci, N, Marsh, PD et al. (1 more author) (2019) Applications of the oral microbiome in personalized dentistry. Archives of Oral Biology, 104. pp. 7-12. ISSN 0003-9969
Abstract
Objective
In the era of personalized medicine, it is imperative that oral health is integrated into this concept. The oral cavity fosters a highly individualized microbiome that has evolved to promote oral health, and which exists in a dynamic balance with the host. Microecological changes to the biology of the mouth [e.g. in the host diet and lifestyle, or status of the immune system] may drive deleterious shifts in the composition or metabolic activity of the oral microbiome [‘dysbiosis’]. This review aims to explore how knowledge of the oral microbiome may be utilized for personalized dentistry at the point-of-care.
Design
This is a comprehensive narrative review of the literature, summarizing the perspectives of the authors.
Results
The huge increase in recent knowledge on the ecology and microbiology of the oral cavity generated by ‘OMIC’ technologies may indeed be clinically translated to support patient care, in terms of prevention, monitoring, risk classification or early diagnosis. The identified clinical applications may not only include dental caries and periodontal disease, but also dental implants and orthodontics. Population-based applications may include systemic health, pregnancy and elderly populations.
Conclusions
Applications of selected oral microbiome and host-related biochemical parameters [e.g. the saliva proteome] for personalized dentistry can be customized for different clinical applications or individual populations, at point-of-care hubs.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Elsevier Ltd. All rights reserved. This is an author produced version of a paper published in Archives of Oral Biology. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Personalized dentistry; Oral microbiome; Oral ecology; Oral disease; Chair-side diagnostics; Point-of-care |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Oral Biology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Jun 2019 14:02 |
Last Modified: | 24 May 2020 00:38 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.archoralbio.2019.05.023 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:147137 |
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