Kerr, A orcid.org/0000-0002-9958-301X, Broer, T, Ross, E et al. (1 more author) (2019) Polygenic risk-stratified screening for cancer: Responsibilization in public health genomics. Social Studies of Science, 49 (4). pp. 605-626. ISSN 0306-3127
Abstract
In this article, we examine professional discourse around the development of polygenic risk-stratified screening (PRSS) for cancer. Analyzing a range of contemporary professional literatures from Europe, North America and Australia, we explore how the drive to screen for molecular markers of cancer risk makes professionals, screening recipients and publics responsible, in different ways, for acquiring, curating and analyzing molecular data. Investigating how these responsibilities are invoked in discussions of new data practices, technologies, organizational arrangements, engagement, education and protocols for participation, we argue that agendas for PRSS for cancer are both expanding and stratifying responsibilities. Data collection is to be achieved by intensified responsibilities for including, reassuring and recruiting populations, as well as by opening and enriching the datasets on which models and preventative screening arrangements are based. Enhanced responsibilities for screening recipients and publics are also invoked, not just in relation to personal health but for population health more generally, via research participation and consenting to data re-use in the public interest. Professionals, screening recipients and publics are also to become responsible for moderating expectations of screening according to genomic designations. Together these discourses go beyond individual risk management to extend and diversify the responsibilities of practitioners, screening recipients and publics as public health genomics develops.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2019. This is an open access article under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) |
Keywords: | genomics; responsibility; risk; screening; stratification |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Education, Social Sciences and Law (Leeds) > School of Sociology and Social Policy (Leeds) |
Funding Information: | Funder Grant number Wellcome Trust 104832/Z/14/Z |
Depositing User: | Symplectic Publications |
Date Deposited: | 06 Jun 2019 14:41 |
Last Modified: | 08 Sep 2019 19:39 |
Status: | Published |
Publisher: | SAGE Publications |
Identification Number: | 10.1177/0306312719858404 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:146685 |