Iali, Wissam orcid.org/0000-0002-9428-2023, Roy, Soumya S orcid.org/0000-0002-9193-9712, Tickner, Ben J et al. (3 more authors) (2019) Hyperpolarizing Pyruvate through Signal Amplification By Reversible Exchange (SABRE). Angewandte Chemie International Edition. pp. 10271-10275. ISSN 1433-7851
Abstract
Hyperpolarization methods that premagnetise agents such as pyruvate are currently receiving significant attention. This is because they produce sensitivity gains that allow disease tracking and interrogation of cellular metabolism by magnetic resonance. Here, we communicate how Signal Amplification by Reversible Exchange (SABRE) can provide strong ¹³C pyruvate signal enhancements in seconds through the formation of the novel polarization transfer catalyst [Ir(H)₂(η²-pyruvate)(DMSO)(IMes)]. By harnessing SABRE, strong signals for 1-¹³C and 2-¹³C pyruvate in addition to a long-lived singlet state in the 1,2-¹³C₂ form are readily created, the latter can be observed five minutes after the initial hyperpolarization step. We also demonstrate how this development may help with future studies of chemical reactivity.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Keywords: | SABRE,catalysis,hyperpolarization,pyruvate,singlet state |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Funding Information: | Funder Grant number MEDICAL RESEARCH COUNCIL (MRC) MR/M008991/1 EPSRC EP/R51181X/1 WELLCOME TRUST 098335/Z/12/Z |
Depositing User: | Pure (York) |
Date Deposited: | 21 May 2019 11:40 |
Last Modified: | 15 Mar 2025 00:08 |
Published Version: | https://doi.org/10.1002/anie.201905483 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1002/anie.201905483 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:146414 |