Cunningham, AC, Hill, L orcid.org/0000-0002-4069-5121, Mon-Williams, M orcid.org/0000-0001-7595-8545 et al. (5 more authors) (2019) Using kinematic analyses to explore sensorimotor control impairments in children with 22q11.2 Deletion Syndrome. Journal of Neurodevelopmental Disorders, 11. 8. ISSN 1866-1947
Abstract
Background: The 22q11.2 deletion is associated with psychiatric and behavioural disorders, intellectual disability and multiple physical abnormalities. Recent research also indicates impaired coordination skills may be part of the clinical phenotype. This study aimed to characterise sensorimotor control abilities in children with 22q11.2 Deletion Syndrome (22q11.2DS) and investigate their relationships with co-occurring IQ impairments and psychopathology.
Methods: 54 children with 22q11.2DS and 24 unaffected sibling controls, comparable in age and gender, underwent kinematic analysis of their hand movements, whilst performing a battery of three visuo-manual coordination tasks that measured their tracking, aiming and steering abilities. Additionally, standardised assessments of full-scale IQ (FSIQ), attention deficit hyperactivity disorder, indicative autism spectrum disorder (ASD) and anxiety disorder symptomatology were conducted.
Results: Children with 22q11.2DS showed deficits on seven of eight kinematic descriptors of movement quality across the three coordination tasks, compared to controls. Within 22q11.2DS cases, the extent of impairment on only three kinematic descriptors was significantly related to FSIQ after correction for multiple testing. Moreover, only error whilst visuo-manually tracking was nominally associated with ADHD symptom counts.
Conclusions: Impairments in sensorimotor control are seen on a range of visuo-manual tasks in children with 22q11.2DS but the extent of these impairments are largely unrelated to the severity of other psychopathological and intellectual impairments commonly found in children with 22q11.2DS.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
Keywords: | 22q11.2 Deletion Syndrome; Movement Difficulties; Coordination; ADHD; ASD; Anxiety |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Psychology (Leeds) |
Funding Information: | Funder Grant number MRC Not Known |
Depositing User: | Symplectic Publications |
Date Deposited: | 22 May 2019 12:52 |
Last Modified: | 25 Jun 2023 21:50 |
Status: | Published |
Publisher: | BMC |
Identification Number: | 10.1186/s11689-019-9271-3 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:146391 |