Wilcox, M orcid.org/0000-0002-4565-2868, Al-Obeid, S, Gales, A et al. (5 more authors) (2019) Reporting elevated vancomycin minimum inhibitory concentration in methicillin-resistant Staphylococcus aureus: Consensus by an International Working Group. Future Microbiology, 14 (4). pp. 345-352. ISSN 1746-0913
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) remains an important cause of serious infection, for which vancomycin is often recommended as the first-choice antibiotic treatment. Appropriate vancomycin prescribing requires accurate measurement of minimum inhibitory concentrations (MICs) to avoid treatment failure, and yet determination can be challenging due to methodological difficulties associated with susceptibility testing. An International Working Group of infectious disease specialists and clinical/medical microbiologists reached a consensus that empirical MRSA infection therapies should be chosen regardless of the suspected origin of the infecting strain (e.g., community or hospital) due to the complex intermingling epidemiology of MRSA clones in these settings. Also, if an elevated vancomycin MIC in the susceptible range is obtained in routine testing, an alternative second method should be used for confirmation and to aid antibiotic therapy recommendations. There is no absolutely dependable method for the accurate determination of vancomycin MIC, but broth microdilution appears to be the most reliable.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Joseph M Blondeau. This is an open access article under the terms of the Attribution-NonCommercial-NoDerivatives 4.0 Unported License. |
Keywords: | CA-MRSA; HA-MRSA; minimum inhibitory concentration; susceptibility; vancomycin |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Molecular Gastroenterology (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 21 May 2019 14:39 |
Last Modified: | 25 Jun 2023 21:50 |
Status: | Published |
Publisher: | Future Medicine |
Identification Number: | 10.2217/fmb-2018-0346 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:146337 |