Richardson, OC, Bane, O, Scott, MLJ et al. (5 more authors) (2015) Gadofosveset‐based biomarker of tissue albumin concentration: Technical validation in vitro and feasibility in vivo. Magnetic Resonance in Medicine, 73 (1). pp. 244-253. ISSN 0740-3194
Abstract
Purpose
There is currently no adequate method of mapping physiologic and pathophysiologic tissue albumin concentrations in human subjects. The objective of this study was to devise and evaluate a biomarker of regional albumin concentration using gadofosveset‐enhanced MRI.
Theory and Methods
A binding and relaxation model was devised and evaluated in vitro in solutions of albumin at 3.0 Tesla (T) and 4.7T. The method was evaluated in the heart in seven volunteers at 3.0T.
Results
MRI‐derived estimates of albumin concentration were in good agreement with true values over the range 0.1–1.0 mM (Pearson correlation coefficients of 0.85 and 0.88 for 3.0T and 4.7T, respectively). The mean calculated albumin concentration in the myocardium for the volunteers was 0.02 mM (range, 0.01–0.03 mM).
Conclusion
Accurate estimates of albumin concentration in vitro suggest this may be a viable noninvasive alternative to existing techniques. In the myocardium the MRI‐derived estimates of albumin concentration indicate the practical feasibility of the technique but were below expected values. Gadofosveset‐enhanced MR relaxometry has potential in providing biomarkers of regional albumin concentration; further evaluation is required before it can be used reliably in vivo. Magn Reson Med 73:244–253, 2015.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 University of Leeds. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/3.0/ |
Keywords: | albumin; binding; biomarker; gadofosveset; relaxivity; Adult; Albumins; Biomarkers; Computer Simulation; Contrast Media; Feasibility Studies; Female; Gadolinium; Heart; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Models, Biological; Molecular Imaging; Myocardium; Organometallic Compounds; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Biomedical Imaging Science Dept (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Genetics, Health and Therapeutics (LIGHT) > Academic Unit of Medical Physics (Leeds) |
Funding Information: | Funder Grant number BBSRC BB/G017220/1 |
Depositing User: | Symplectic Publications |
Date Deposited: | 02 Jul 2019 14:58 |
Last Modified: | 02 Jul 2019 14:58 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/mrm.25128 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:146245 |