Godazandeh, K, Sosa, SM, Wu, J orcid.org/0000-0001-6093-599X et al. (1 more author) (2019) Trigeminal neuralgia: Comparison of characteristics and impact in patients with or without multiple sclerosis. Multiple Sclerosis and Related Disorders, 34. pp. 41-46. ISSN 2211-0348
Abstract
Objectives
The commonest secondary cause for trigeminal neuralgia (TN) is multiple sclerosis (MS) and little is known about this group of patients in terms of their presentation and treatments. We compared patients with TN and MS (pwTNMS) with a cohort of patients with primary TN, who had been referred to the same specialist unit, both in terms of characteristics and impact on quality of life at the time of their first assessment.
Methods
Using a prospective patient database we extracted key clinical data and results from psychometrically tested questionnaires of 26 pwTNMS and compared them to an age and gender-matched set of 68 patients with primary TN.
Results
Our findings suggest that pwTNMS exhibit a more severe clinical phenotype than primary TN. Prior to referral, pwTNMS are more likely to have used more healthcare services and undergone more neurosurgical interventions. Strikingly, pwTNMS exhibit reduced lengths and duration of remission periods and fewer identifiable triggers. Furthermore, pwTNMS report significant impact on quality of life comparable to those in primary TN, scoring highly in measures of anxiety, depression, and catastrophizing, but also report greater sleep disturbance, and overall interference in activities of daily living.
Conclusions
pwTNMS have a more intractable TN, one which may necessitate a more complex approach to treatment, earlier referral to secondary care and an extensive assessment of mental health. Quality of life in pwTNMS is severely affected by both their MS and their TN, suggesting management should occur in specialist centres with access to a multidisciplinary team.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2019 Elsevier B.V. All rights reserved. This is an author produced version of an article published in Multiple Sclerosis and Related Disorders. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Trigeminal neuralgia; Multiple sclerosis; Case control |
Dates: |
|
Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Applied Health and Clinical Translation (Leeds) |
Funding Information: | Funder Grant number Multiple Sclerosis Society 91 |
Depositing User: | Symplectic Publications |
Date Deposited: | 14 May 2019 13:11 |
Last Modified: | 17 Jun 2020 00:38 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.msard.2019.06.015 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:146014 |
Download
Filename: 181210 Trigeminal neuralgia and MS case control.pdf
Licence: CC-BY-NC-ND 4.0