Johnston, J orcid.org/0000-0002-9928-989X, Seibel, S-H, Darnet, LSA et al. (3 more authors) (2019) A Retinal Circuit Generating a Dynamic Predictive Code for Oriented Features. Neuron, 102 (6). 1211-1222.e3. ISSN 0896-6273
Abstract
Sensory systems must reduce the transmission of redundant information to function efficiently. One strategy is to continuously adjust the sensitivity of neurons to suppress responses to common features of the input while enhancing responses to new ones. Here we image the excitatory synaptic inputs and outputs of retinal ganglion cells to understand how such dynamic predictive coding is implemented in the analysis of spatial patterns. Synapses of bipolar cells become tuned to orientation through presynaptic inhibition, generating lateral antagonism in the orientation domain. Individual ganglion cells receive excitatory synapses tuned to different orientations, but feedforward inhibition generates a high-pass filter that only transmits the initial activation of these inputs, removing redundancy. These results demonstrate how a dynamic predictive code can be implemented by circuit motifs common to many parts of the brain.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | Crown Copyright © 2019 Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | Vision; Retina; Zebrafish; Tectum; Synapse; Orientation; Predictive code |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Biomedical Sciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 03 May 2019 11:34 |
Last Modified: | 25 Jun 2023 21:48 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.neuron.2019.04.002 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:145624 |