Kirkham, CM and Boyes, J orcid.org/0000-0002-8705-9827 (2019) Genome instability triggered by the V(D)J recombination by-product. Molecular and Cellular Oncology, 6 (4). 1610323. ISSN 2372-3556
Abstract
A newly identified process by which mistargeted V(D)J recombination could cause genome instability in childhood leukemia has been discovered. In this mechanism, called cut-and-run, the excised DNA by-products of V(D)J recombination are re-bound by the recombinase proteins and erroneously trigger double-strand breaks at multiple locations throughout the genome. Many of these breakpoints co-localize with known chromosome alterations in acute lymphoblastic leukemia (ALL).
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019, Taylor & Francis Group, LLC. This is an Accepted Manuscript of an article published by Taylor & Francis Group in Molecular & Cellular Oncology on 07/05/2019, available online: https://www.tandfonline.com/10.1080/23723556.2019.1610323 |
Keywords: | V(D)J recombination; double strand breaks; chromosome translocations; RAG recombinase; genome instability; acute lymphoblastic leukemia |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Molecular & Cellular Biology (Leeds) |
Funding Information: | Funder Grant number Bloodwise 15042 |
Depositing User: | Symplectic Publications |
Date Deposited: | 01 May 2019 10:56 |
Last Modified: | 07 May 2020 00:39 |
Status: | Published |
Publisher: | Taylor and Francis |
Identification Number: | 10.1080/23723556.2019.1610323 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:145528 |