Johnson, CA orcid.org/0000-0002-2979-8234 and Malicki, JJ (2019) The Nuclear Arsenal of Cilia. Developmental Cell, 49 (2). pp. 161-170. ISSN 1534-5807
Abstract
Several recent studies have revealed that nuclei and cilia share molecular components implicated in DNA damage response, splicing, gene expression, and sub-compartmentalization of the cell. We review evidence that exchange of components between the nucleus and cilia is facilitated by the centrosome, which contributes both to the mitotic apparatus of the nucleus and to the cilia structure. Moreover, the centrosome and the pericentriolar material form condensates that share components with stress granules and P-bodies, membrane-less organelles enriched in RNA and RNA-processing proteins. These features may largely explain the origin of similar molecular mechanisms in nuclei and cilia.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Elsevier Inc. This is an author produced version of a paper published in Developmental Cell. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | cilia; nucleus; nuclear pore; transport; basal body; mitosis; evolution |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > Institute of Molecular Medicine (LIMM) (Leeds) > Section of Opthalmology and Neurosciences (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 01 May 2019 12:49 |
Last Modified: | 22 Apr 2020 00:38 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.devcel.2019.03.009 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:145513 |
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Filename: Johnson & Malicki 2019 final author accepted.pdf
Licence: CC-BY-NC-ND 4.0