Sherwood, James Richard orcid.org/0000-0001-5431-2032, Clark, James Hanley orcid.org/0000-0002-5860-2480, Fairlamb, Ian James Stewart orcid.org/0000-0002-7555-2761 et al. (1 more author) (2019) Solvent effects in palladium catalysed cross-coupling reactions. Green Chemistry. pp. 2164-2213. ISSN 1463-9270
Abstract
Palladium catalysed cross-couplings reactions have been a dominant method in synthetic chemistry for decades. Despite this, the role of the solvent is often taken for granted and poorly understood. Regulations affecting some the most frequently used solvents for cross-coupling reactions are accelerating current trends towards using new types of solvents. In this review, the fundamental interactions between solvent and catalyst are explained so that it may inform the rational selection of high performance and safe solvents. The popular cross-coupling methodologies are addressed (Suzuki, Stille, Kumada, Negishi, Hiyama, Heck, Sonogashira, and Buchwald–Hartwig reactions) and novel solvents introduced.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2019. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Keywords: | palladium,catalysis,solvents,CROSS-COUPLING REACTION,MECHANISM |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) |
Depositing User: | Pure (York) |
Date Deposited: | 29 Apr 2019 10:50 |
Last Modified: | 02 Apr 2025 23:15 |
Published Version: | https://doi.org/10.1039/C9GC00617F |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1039/C9GC00617F |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:145455 |
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Filename: Solvents_for_x_coupling_accepted_manuscript_.pdf
Description: Solvents for x-coupling (accepted manuscript)