Dubée, V., Bernut, A. orcid.org/0000-0002-1928-8329, Cortes, M. et al. (10 more authors) (2014) β-lactamase inhibition by avibactam in Mycobacterium abscessus. Journal of Antimicrobial Chemotherapy, 70 (4). pp. 1051-1058. ISSN 0305-7453
Abstract
Two β-lactams, cefoxitin and imipenem, are part of the reference treatment for pulmonary infections with Mycobacterium abscessus. M. abscessus has recently been shown to produce a broad-spectrum β-lactamase, BlaMab, indicating that the combination of β-lactams with a BlaMab inhibitor may improve treatment efficacy. The objectives of this study were to evaluate the impact of BlaMab production on the efficacy of β-lactams in vitro and to assess the benefit of BlaMab inhibition on the activity of β-lactams intracellularly and in an animal model.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2014 The Authors. |
Keywords: | non-tuberculous mycobacteria; M. abscessus; therapy; β-lactams; cystic fibrosis |
Dates: |
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Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Medicine, Dentistry and Health (Sheffield) |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 08 Aug 2019 13:01 |
Last Modified: | 08 Aug 2019 13:02 |
Status: | Published |
Publisher: | Oxford University Press |
Refereed: | Yes |
Identification Number: | 10.1093/jac/dku510 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:145425 |