Co, JL, Swain, M, Murray, LJ orcid.org/0000-0003-0658-6455 et al. (7 more authors) (2019) Meningioma Screening with MRI in Childhood Leukemia Survivors Treated with Cranial Radiation. International journal of Radiation Oncology*Biology*Physics, 104 (3). pp. 640-643. ISSN 0360-3016
Abstract
Purpose:
Radiation induced meningioma (RIM) is a known late effect of cranial radiotherapy. Cranial MRI can detect small meningiomas, but its potential value as a screening tool is unknown.
Methods and Materials:
MRI was used to screen asymptomatic survivors of childhood ALL treated with CRT ≥10 years previously. The incidence of RIM and outcomes of this group were compared with a historical cohort of survivors with the same exposure who underwent imaging only to investigate clinical signs or symptoms.
Results:
176 childhood leukemia survivors were included in this study, 70 in the screening group, 106 unscreened. Screening MRI was performed a median of 25 years post-RT and detected meningioma in 15 (21.4%). In the unscreened group, 17 patients (16.0%) had neurologic symptoms leading to an MRI after a median interval of 24 years following RT, 9 of whom (8.5%) were diagnosed with meningioma. There was no significant difference between screened vs. unscreened patients in the size of meningioma (mean diameter 1.6cm vs 2.6cm; p =0.13), meningioma incidence (7.4% vs. 4.0% at 25 years; p =0.19), or extent of resection. There were 3 patients who had persistent neurologic symptoms in the unscreened group versus none in among screened patients (p= 0.28).
Conclusion:
Screening MRI was able to detect small meningiomas that were not clinically apparent, however we could not demonstrate a significant improvement in the chance of total resection or a significant decrease in morbidity. A larger sample could clarify potential reduction in neurologic sequelae associated with screening.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019, Elsevier Ltd. All rights reserved. This is an author produced version of a paper published in International Journal of Radiation Oncology, Biology, Physics. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Clinical Cancer Research (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 26 Apr 2019 14:59 |
Last Modified: | 14 Mar 2020 01:39 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.ijrobp.2019.02.057 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:145358 |
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