Wilson, Alison Jane, Webster, Andrew Joseph orcid.org/0000-0002-5782-0793 and Genever, Paul Gilbert orcid.org/0000-0002-5730-8976 (2019) Nomenclature and heterogeneity:consequences for the use of mesenchymal stem cells in regenerative medicine. REGENERATIVE MEDICINE. pp. 595-611. ISSN 1746-0751
Abstract
Mesenchymal stem cells (MSCs) are in development for many clinical indications, based both on “stem” properties (tissue repair or regeneration) and on signalling repertoire (immunomodulatory and anti-inflammatory effects). Potential conflation of MSC properties with those of tissue-derived stromal cells presents difficulties in comparing study outcomes and represents a source of confusion in cell therapy development. Cultured MSCs demonstrate significant heterogeneity in clonogenicity and multi-lineage differentiation potential. However in vivo biology of MSCs includes native functions unrelated to regenerative medicine applications, so do nomenclature and heterogeneity matter? In this perspective we examine some consequences of the nomenclature debate and heterogeneity of MSCs. Regulatory expectations are considered, emphasising that product development should prioritise detailed characterisation of therapeutic cell populations for specific indications.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 AJ Wilson, AJ Webster, PG Genever |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Biology (York) The University of York > Faculty of Social Sciences (York) > Sociology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 24 Apr 2019 10:50 |
Last Modified: | 19 Oct 2024 00:01 |
Published Version: | https://doi.org/10.2217/rme-2018-0145 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.2217/rme-2018-0145 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:145315 |
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Filename: rme_2018_0145.pdf
Description: Nomenclature and heterogeneity: consequences for the use of mesenchymal stem cells in regenerative medicine
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