Philippou, H (2019) Heavy chain of FXII: not an innocent bystander! Blood, 133 (10). pp. 1008-1009. ISSN 0006-4971
Abstract
In this issue of Blood, Ivanov et al1 have identified that the N-terminal noncatalytic heavy chain of factor XII (FXII) plays an important role in the regulation of activation of the contact pathway of coagulation by the reciprocal activation of FXII and prekallikrein (PK). This mechanism provides insights into the clinical manifestation of an edema outbreak in patients with a rare form of hereditary angioedema (HAE).
Metadata
| Item Type: | Article |
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| Authors/Creators: |
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| Dates: |
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| Institution: | The University of Leeds |
| Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) |
| Depositing User: | Symplectic Publications |
| Date Deposited: | 24 Apr 2019 13:03 |
| Last Modified: | 24 Apr 2019 13:03 |
| Status: | Published |
| Publisher: | American Society of Hematology |
| Identification Number: | 10.1182/blood-2019-01-895110 |
| Related URLs: | |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:145256 |
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