Haworth, Alexander and Brackenbury, William John orcid.org/0000-0001-6882-3351 (2019) Emerging roles for multifunctional ion channel auxiliary subunits in cancer. Cell calcium. pp. 125-140. ISSN 0143-4160
Abstract
Several superfamilies of plasma membrane channels which regulate transmembrane ion flux have also been shown to regulate a multitude of cellular processes, including proliferation and migration. Ion channels are typically multimeric complexes consisting of conducting subunits and auxiliary, non-conducting subunits. Auxiliary subunits modulate the function of conducting subunits and have putative non-conducting roles, further expanding the repertoire of cellular processes governed by ion channel complexes to processes such as transcellular adhesion and gene transcription. Given this expansive influence of ion channels on cellular behaviour it is perhaps no surprise that aberrant ion channel expression is a common occurrence in cancer. This review will focus on the conducting and non-conducting roles of the auxiliary subunits of various Ca2+, K+, Na+ and Cl- channels and the burgeoning evidence linking such auxiliary subunits to cancer. Several subunits are upregulated (e.g. Cavβ, Cavγ) and downregulated (e.g. Kvβ) in cancer, while other subunits have been functionally implicated as oncogenes (e.g. Navβ1, Cavα2δ1) and tumour suppressor genes (e.g. CLCA2, KCNE2, BKγ1) based on in vivo studies. The strengthening link between ion channel auxiliary subunits and cancer has exposed these subunits as potential biomarkers and therapeutic targets. However further mechanistic understanding is required into how these subunits contribute to tumour progression before their therapeutic potential can be fully realised.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2019 The Authors. Published by Elsevier Ltd. |
Keywords: | Auxiliary subunit,Calcium channel,Cancer,Chloride channel,Potassium channel,Sodium channel |
Dates: |
|
Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Chemistry (York) The University of York > Faculty of Sciences (York) > Biology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 18 Apr 2019 15:30 |
Last Modified: | 24 Oct 2024 00:05 |
Published Version: | https://doi.org/10.1016/j.ceca.2019.04.005 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1016/j.ceca.2019.04.005 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:145144 |
Download
Filename: 1_s2.0_S014341601930051X_main.pdf
Description: 1-s2.0-S014341601930051X-main
Licence: CC-BY-NC-ND 2.5