Jiménez-Sáncheza, M, Pérez-Morales, R, Goycoolea Valencia, F orcid.org/0000-0001-7949-5429 et al. (7 more authors) (2019) Self-assembled high molecular weight inulin nanoparticles: Enzymatic synthesis, physicochemical and biological properties. Carbohydrate Polymers, 215. pp. 160-169. ISSN 1879-1344
Abstract
Inulin has interesting physicochemical and functional properties, and therefore a wide range of applications in the food and medical industries. It has gained great traction due to its ability to form nanoparticles and its possible application as nanovehicle for drug delivery. In this work, we demonstrated that the enzymatically-synthesized high molecular weight (HMW) inulin forms stable spherical nanoparticles with an average diameter of 112 ± 5 nm. The self-assemblage of HMW inulin nanoparticles is carried out during enzymatic synthesis of the polymer, and become detectable after a certain critical aggregation concentration (CAC) is reached. Both, the CAC and nanoparticle size are influenced by the reaction temperature. These nanoparticles are not toxic for peripheral blood mononuclear cells, at concentrations below 200 μg/mL; no significant prebiotic potential was detected in cultures of 13 probiotic strains. This work contributes to a better understanding of the formation of HMW inulin nanoparticles and their biological properties.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 Elsevier Ltd. All rights reserved. This is an author produced version of a paper published in Carbohydrate Polymers. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | Inulin; Polysaccharide nanoparticles; Enzymatic synthesis; Fructan; Inulosucrase |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Environment (Leeds) > School of Food Science and Nutrition (Leeds) > FSN Chemistry and Biochemistry (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 11 Apr 2019 09:05 |
Last Modified: | 18 Mar 2020 01:38 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.carbpol.2019.03.060 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:144818 |
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