Development and Validation of an OMERACT MRI Whole-Body Score for Inflammation in Peripheral Joints and Entheses in Inflammatory Arthritis (MRI-WIPE)

Abstract

Objective: To develop a whole-body MRI-scoring system for peripheral arthritis and enthesitis.

Methods: After consensus on definitions/locations of MRI pathologies, four multi-reader exercises were performed. Eighty-three joints were scored 0-3 separately for synovitis and osteitis, thirty-three entheses 0-3 separately for soft tissue inflammation and osteitis.

Results: In the last exercise, reliability was moderate-good for musculoskeletal radiologists and rheumatologists with previously demonstrated good scoring proficiency. Median pairwise single-measure/average-measure ICCs were 0.67/0.80 for status scores and 0.69/0.82 for change scores; kappas ranged 0.35-0.77.

Conclusion: WBMRI scoring of peripheral arthritis and enthesitis is reliable which encourages further testing and refinement in clinical trials.

Metadata

Item Type:	Article
Authors/Creators:	Krabbe, S Eshed, I Gandjbakhch, F Pedersen, SJ Bird, P Mathew, AJ Lambert, RG Maksymowych, WP Glinatsi, D Stoenoiu, MS Poggenborg, R Jans, L Jaremko, JL Herregods, N Foltz, V Conaghan, PG https://orcid.org/0000-0002-3478-5665 Althoff, CE Paschke, J Peterfy, C Hermann, K-GA Østergaard, M
Copyright, Publisher and Additional Information:	© 2019 The Journal of Rheumatology. This is a pre-copyediting, author-produced PDF of an article accepted for publication in The Journal of Rheumatology following peer review. The definitive publisher-authenticated version Krabbe, S, Eshed, I, Gandjbakhch, F et al. (2019) Development and Validation of an OMERACT MRI Whole-Body Score for Inflammation in Peripheral Joints and Entheses in Inflammatory Arthritis (MRI-WIPE). The Journal of Rheumatology. ISSN 0315-162X is available online at: https://doi.org/10.3899/jrheum.181084.
Keywords:	Magnetic Resonance Imaging; Outcome Assessment; Arthritis; Omeract
Dates:	Published: 1 September 2019 Published (online): 15 February 2019 Accepted: 24 January 2019
Institution:	The University of Leeds
Academic Units:	The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Institute of Rheumatology & Musculoskeletal Medicine (LIRMM) (Leeds) > Musculoskeletal Medicine & Imaging (Leeds)
Depositing User:	Symplectic Publications
Date Deposited:	03 Apr 2019 10:17
Last Modified:	15 Feb 2020 01:38
Status:	Published
Publisher:	Journal of Rheumatology
Identification Number:	10.3899/jrheum.181084
Related URLs:	PubMed URL
Open Archives Initiative ID (OAI ID):	oai:eprints.whiterose.ac.uk:144391

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Development and Validation of an OMERACT MRI Whole-Body Score for Inflammation in Peripheral Joints and Entheses in Inflammatory Arthritis (MRI-WIPE)

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