Ashcroft, AE orcid.org/0000-0002-1676-123X (2019) Mass spectrometry-based studies of virus assembly. Current Opinion in Virology, 36. pp. 17-24. ISSN 1879-6257
Abstract
The assembly of exact numbers of protein monomers into the distinct architectures of virus capsids has long been of intrigue. Despite the diseases associated with viruses, there is a paucity of anti-viral therapies; however, mapping virus capsid assembly at the molecular level may lead to the development of more therapeutics. Native mass spectrometry is a powerful, versatile tool with which to monitor biomolecular assembly pathways and identify key intermediates. Recent highlights in this field in terms of MDa mass measurements, identification of capsid intermediates, and the effect of external parameters on assembly are discussed. Examples from ion mobility spectrometry-mass spectrometry, charge detection mass spectrometry, and gas-phase electrophoretic molecular analysis research are presented.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Biological Sciences (Leeds) > School of Molecular and Cellular Biology (Leeds) > Biomolecular Mass Spectroscopy (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 28 Mar 2019 09:44 |
Last Modified: | 28 Mar 2019 09:49 |
Status: | Published |
Publisher: | Elsevier |
Identification Number: | 10.1016/j.coviro.2019.02.006 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:144188 |