Waduud, MA orcid.org/0000-0001-5567-9952, Wood, B, Keleabetswe, P et al. (7 more authors) (2019) Influence of psoas muscle area on mortality following elective abdominal aortic aneurysm repair. British Journal of Surgery, 106 (4). pp. 367-374. ISSN 0007-1323
Abstract
Background: The effect of sarcopenia based on the total psoas muscle area (TPMA) on CT is inconclusive in patients undergoing abdominal aortic aneurysm (AAA) intervention. The aim of this prospective cohort study was to evaluate morphometric sarcopenia as a method of risk stratification in patients undergoing elective AAA intervention. Methods: TPMA was measured on preintervention CT images of patients undergoing elective endovascular aneurysm repair (EVAR) or open aneurysm repair. Mortality was assessed in relation to preintervention TPMA using Cox regression analysis, with calculation of hazard ratios at 30 days, 1 year and 4 years. Postintervention morbidity was evaluated in terms of postintervention care, duration of hospital stay and 30‐day readmission. Changes in TPMA on surveillance EVAR imaging were also evaluated. Results: In total, 382 patient images acquired between March 2008 and December 2016 were analysed. There were no significant intraobserver and interobserver differences in measurements of TPMA. Preintervention TPMA failed to predict morbidity and mortality at all time points. The mean(s.d.) interval between preintervention and surveillance imaging was 361·3(111·2) days. A significant reduction in TPMA was observed in men on surveillance imaging after EVAR (mean reduction 0·63(1·43) cm2 per m2; P < 0·001). However, this was not associated with mortality (adjusted hazard ratio 1·00, 95 per cent c.i. 0·99 to 1·01; P = 0·935). Conclusion: TPMA is not a suitable risk stratification tool for patients undergoing effective intervention for AAA.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © 2019 BJS Society Ltd. Published by John Wiley & Sons Ltd This is the peer reviewed version of the following article: Waduud, M. A., Wood, B. , Keleabetswe, P. , Manning, J. , Linton, E. , Drozd, M. , Hammond, C. J., Bailey, M. A., Scott, D. J. and , (2019), Influence of psoas muscle area on mortality following elective abdominal aortic aneurysm repair. Br J Surg, 106: 367-374., which has been published in final form at https://doi.org/10.1002/bjs.11074. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Uploaded in accordance with the publisher's self-archiving policy. |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) > Discovery & Translational Science Dept (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 26 Mar 2019 13:36 |
Last Modified: | 31 Jan 2020 01:39 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1002/bjs.11074 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:144082 |