Guo, S, Wu, J orcid.org/0000-0001-6093-599X, Ding, M et al. (1 more author) (2008) Uncovering Interactions in the Frequency Domain. PLoS Computational Biology, 4 (5). e1000087. ISSN 1553-734X
Abstract
Oscillatory activity plays a critical role in regulating biological processes at levels ranging from subcellular, cellular, and network to the whole organism, and often involves a large number of interacting elements. We shed light on this issue by introducing a novel approach called partial Granger causality to reliably reveal interaction patterns in multivariate data with exogenous inputs and latent variables in the frequency domain. The method is extensively tested with toy models, and successfully applied to experimental datasets, including (1) gene microarray data of HeLa cell cycle; (2) in vivo multi-electrode array (MEA) local field potentials (LFPs) recorded from the inferotemporal cortex of a sheep; and (3) in vivo LFPs recorded from distributed sites in the right hemisphere of a macaque monkey.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | (c) 2008 Guo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
Keywords: | Transcription factors; Time domain analysis; Genetic networks; Neural networks; HeLa cells; Sheep; Microarrays; Right hemisphere |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Dentistry (Leeds) > Applied Health and Clinical Translation (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 09 Sep 2019 10:58 |
Last Modified: | 09 Sep 2019 10:58 |
Status: | Published |
Publisher: | Public Library of Science |
Identification Number: | 10.1371/journal.pcbi.1000087 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143968 |