Abbas, L. and Rivolta, M.N. orcid.org/0000-0003-4178-8570 (2019) The use of animal models to study cell transplantation in neuropathic hearing loss. Hearing Research, 377. pp. 72-87. ISSN 0378-5955
Abstract
Auditory neuropathy (AN) is a form of sensorineural deafness specifically affecting the conduction of the nerve impulse from the cochlear hair cells to the auditory centres of the brain. As such, the condition is a potential clinical target for ‘cell replacement therapy’, in which a functioning auditory nerve is regenerated by transplanting an appropriated neural progenitor.
In this review, we survey the current literature and examine possible experimental models for this condition, with particular reference to their compatibility as suitable hosts for transplantation. The use of exogenous neurotoxic agents such as ouabain or β-bungarotoxin is discussed, as are ageing and noise-induced synaptopathy models. Lesioning of the nerve by mechanical damage during surgery and the neuropathy resulting from infectious diseases may be very relevant clinically, and we discuss whether there are good models for these situations. We also address genetic models for AN, examining whether the phenotypes truly model the clinical situation in their human counterpart syndromes - we use the example of the hyperbilirubinaemic Gunn rat as a particular instance in this regard.
Metadata
Item Type: | Article |
---|---|
Authors/Creators: |
|
Copyright, Publisher and Additional Information: | © 2019 Elsevier. This is an author produced version of a paper subsequently published in Hearing Research. Uploaded in accordance with the publisher's self-archiving policy. Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
Dates: |
|
Institution: | The University of Sheffield |
Academic Units: | The University of Sheffield > Faculty of Science (Sheffield) > School of Biosciences (Sheffield) > Department of Biomedical Science (Sheffield) |
Funding Information: | Funder Grant number EUROPEAN COMMISSION - FP6/FP7 603029 MEDICAL RESEARCH COUNCIL MR/L013320/1 |
Depositing User: | Symplectic Sheffield |
Date Deposited: | 20 Mar 2019 12:24 |
Last Modified: | 22 Nov 2021 09:27 |
Status: | Published |
Publisher: | Elsevier |
Refereed: | Yes |
Identification Number: | 10.1016/j.heares.2019.03.014 |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143888 |
Download
Filename: Models for cell transplant in AN_Abbas & Rivolta_AM.pdf
Licence: CC-BY-NC-ND 4.0