Hong, Seok Jun, de Wael, Reinder Vos, Bethlehem, Richard A.I. et al. (8 more authors) (2019) Atypical functional connectome hierarchy in autism. Nature Communications. 1022. ISSN 2041-1723
Abstract
One paradox of autism is the co-occurrence of deficits in sensory and higher-order socio-cognitive processing. Here, we examined whether these phenotypical patterns may relate to an overarching system-level imbalance—specifically a disruption in macroscale hierarchy affecting integration and segregation of unimodal and transmodal networks. Combining connectome gradient and stepwise connectivity analysis based on task-free functional magnetic resonance imaging (fMRI), we demonstrated atypical connectivity transitions between sensory and higher-order default mode regions in a large cohort of individuals with autism relative to typically-developing controls. Further analyses indicated that reduced differentiation related to perturbed stepwise connectivity from sensory towards transmodal areas, as well as atypical long-range rich-club connectivity. Supervised pattern learning revealed that hierarchical features predicted deficits in social cognition and low-level behavioral symptoms, but not communication-related symptoms. Our findings provide new evidence for imbalances in network hierarchy in autism, which offers a parsimonious reference frame to consolidate its diverse features.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Author(s) 2019. |
Keywords: | Adolescent,Adult,Autistic Disorder/diagnostic imaging,Cerebral Cortex/pathology,Connectome,Female,Humans,Magnetic Resonance Imaging/methods,Male,Motion,Nerve Net/pathology,Social Behavior Disorders/pathology,Young Adult |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > Faculty of Sciences (York) > Psychology (York) |
Depositing User: | Pure (York) |
Date Deposited: | 19 Mar 2019 16:10 |
Last Modified: | 16 Oct 2024 15:34 |
Published Version: | https://doi.org/10.1038/s41467-019-08944-1 |
Status: | Published |
Refereed: | Yes |
Identification Number: | 10.1038/s41467-019-08944-1 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143864 |