Renehan, AG, Muirhead, R, Berkman, L et al. (3 more authors) (2019) Early stage anal margin cancer: towards evidence-based management. Colorectal Disease. ISSN 1462-8910
Abstract
Anal squamous cell carcinoma is an uncommon Human Papilloma Virus (HPV)‐related malignancy, the incidence of which has increased two‐ to four‐fold over the past three decades. Results from the first three phase III trials, performed in the 1990s (the largest being the ACT I trial in the UK), established concurrent mitomycin C (MMC), 5‐fluorouracil chemotherapy and radiotherapy (CRT) as the main primary treatment. Three subsequent trials (including ACT II in the UK, performed between 1998 and 2008, demonstrated evidence of no benefit from the use of additional chemotherapy before or after CRT, or concurrent cisplatin.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | This article is protected by copyright. All rights reserved. This is the peer reviewed version of the following article: Renehan, A. G., Muirhead, R., Berkman, L., McParland, L., Sebag‐Montefiore, D. and, PLATO trial management group (2019) Early stage anal margin cancer: towards evidence‐based management. Colorectal Dis., which has been published in final form at https://doi.org/10.1111/codi.14571. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. Uploaded in accordance with the publisher's self-archiving policy. |
Keywords: | anal cancer; local excision; chemo‐radiotherapy |
Dates: |
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Institution: | The University of Leeds |
Academic Units: | The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Leeds Institute of Cancer and Pathology (LICAP) > Clinical Cancer Research (Leeds) The University of Leeds > Faculty of Medicine and Health (Leeds) > School of Medicine (Leeds) > Inst of Clinical Trials Research (LICTR) (Leeds) |
Depositing User: | Symplectic Publications |
Date Deposited: | 20 Mar 2019 14:22 |
Last Modified: | 29 Jun 2020 13:36 |
Status: | Published |
Publisher: | Wiley |
Identification Number: | 10.1111/codi.14571 |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143857 |