Munoz-Menendez, Cristina, Conde-Leboran, Ivan, Serantes, David et al. (3 more authors) (2016) Distinguishing between heating power and hyperthermic cell-treatment efficacy in magnetic fluid hyperthermia. Soft Matter. pp. 8815-8818. ISSN 1744-683X
Abstract
In the magnetic fluid hyperthermia (MFH) research field, it is usually assumed that achieving a uniform temperature enhancement (ΔT) of the entire tumour is a key-point for treatment. However, various experimental works reported successful cell apoptosis via MFH without a noticeable ΔT of the system. A possible explanation of the success of these negligible-ΔT experiments is that a local ΔT restricted to the particle nanoenvironment (i.e. with no significant effect on the global temperature T) could be enough to trigger cell death. Shedding light on such a possibility requires accurate knowledge of heat dissipation at the local level in relation to the usually investigated global (average) one. Since size polydispersity is inherent to all synthesis techniques and the heat released is proportional to the particle size, heat dissipation spots with different performances-and thus different effects on the cells-will likely exist in every sample. In this work we aim for a double objective: (1) to emphasize the necessity to distinguish between the total dissipated heat and hyperthermia effectiveness, and (2) to suggest a theoretical approach on how to select, for a given size polydispersity, a more adequate average size so that most of the particles dissipate within a desired heating power range. The results are reported in terms of Fe3O4 nanoparticles as a representative example.
Metadata
Item Type: | Article |
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Authors/Creators: |
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Copyright, Publisher and Additional Information: | © The Royal Society of Chemistry 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
Dates: |
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Institution: | The University of York |
Academic Units: | The University of York > York Institute for Materials Research The University of York > Faculty of Sciences (York) > Physics (York) |
Depositing User: | Pure (York) |
Date Deposited: | 15 Mar 2019 13:00 |
Last Modified: | 16 Oct 2024 15:14 |
Published Version: | https://doi.org/10.1039/c6sm01910b |
Status: | Published online |
Refereed: | Yes |
Identification Number: | 10.1039/c6sm01910b |
Related URLs: | |
Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:143719 |